Acetaminophen is used to relieve mild to go over pain from headaches, muscle aches, menstrual periods, colds and sore throats, toothaches, backaches, and reactions to vaccinations (shots), and to reduce fever. Preparation of acetaminophen involves treating an amine (p-aminophenol, with an acid anhydride to form acetaminophen (p-acetamidophenol), the amide.
routine: Preparation of Acetaminophen
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Procedure:
1. Reaction Mixture-1.5 g of p-aminophenol (MW=109.1) was placed in 50 ml Erlenmeyer flask. With a graduate cylinder I added 4.5 ml of water and 1.7 ml of acetic anhydride (MW=102.1, d=1.08g/ml) too I placed magnetic stir bar in the flask and than I heat the diverseness.
2. Isolation of Crude Acetaminophen- I removed the flask from the hot plate to cool to style temperature. After crystallization has occurred, I cool the categorization in an ice bath and collect the crystals by vacuum filtration on a vitiated Buchner funnel. I allowed the crystals to dry and I encumbrance the crude product and measured the melting point. Latter I calculate the percentage yield.
3. Decolarization of Crude Acetaminophen 2.0 g of atomic number 11 dithionite was turn in 15 ml of water in a 50 ml Erlenmeyer flask.
The crude acetaminophen was added to the flask. The mixture was heat and some of the acetaminophen dissolved during the process. Then the mixture was cold in an ice bath for 10 min. The purified worldly was collected by vacuum filtration on a small Buchner funnel. After the crystals were dry the purified acetaminophen was weight and I ascertained the color.
4. Crystallization of Acetaminophen-the purified acetaminophen was placed in a 50 ml Erlenmeyer flask. The material from a solvent mixture was compose of 50% water and 50% methanol by volume. The solubility of acetaminophen in this solvent was:1g/5ml. After the solid dissolved the mixture was cool to room temperature and the flask was placed in ice bath. The crystals...If you want to get a full essay, instal it on our website: Orderessay
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